B&H has the Lowepro Pro Runner x450 Rolling AW backpack for $149.99 (reg. $369.99) in limited quantity. The x450 can carry a pro-sized DSLR with a 300mm f/2.8 lens attached and 4-6 additional lenses, flash and accessories. It also has a laptop pouch for up to a 15.4″ laptop. Check it out here at B&H Photo.